Prescribed as an aid for smoking cessation, bupropion reduces the severity of craving for nicotine and withdrawal symptoms such as depressed mood, irritability, difficulty concentrating, and increased appetite. Initially, bupropion slows the weight gain that often occurs in the first weeks after quitting smoking.

Off-Label Uses: The Nootropic, bupropion (Wellbutrin), provides a more robust stimulation of key brain architecture and without the side effects of methylphenidate (Ritalin). Resultantly, in the treatment of ADHD, bupropion has proved superior to methylphenidate in clinical trials.